BDBM50011504 CHEMBL3261928

SMILES CN1Cc2ccc(cc2C1=O)-c1ccc(C[C@H](NC(=O)C2(N)CCOCC2)C#N)cc1

InChI Key InChIKey=ALYPEORYGVOPDI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50011504   

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50011504(CHEMBL3261928)
Affinity DataIC50: 50nMAssay Description:Inhibition of cathepsin C in human THP1 cells assessed as inhibition of H-Gly-Phe-AFC cleavage by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
LigandPNGBDBM50011504(CHEMBL3261928)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human ERG by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetCathepsin K(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50011504(CHEMBL3261928)
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibition of Cathepsin K (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50011504(CHEMBL3261928)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human cathepsin C using H-Gly-Arg-AMC as substrate preincubated for 30 mins before substrate addition measured after 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed