BDBM50011247 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol; hydrobromide::CHEMBL41436::CHEMBL541621::S-(-)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol

SMILES CCCN(CCC)[C@H]1CCc2cccc(O)c2C1

InChI Key InChIKey=ASXGJMSKWNBENU-UHFFFAOYSA-N

Data  11 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50011247   

Target5-hydroxytryptamine receptor 1A(Rat)
University of Uppsala

Curated by ChEMBL
LigandPNGBDBM50011247(S-(-)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthale...)
Affinity DataIC50: 6.5nMAssay Description:Concentration of compound required to inhibit cortical 5-hydroxytryptamine 1A receptor binding sites in rat brain was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Uppsala

Curated by ChEMBL
LigandPNGBDBM50011247(S-(-)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthale...)
Affinity DataIC50: 4nMAssay Description:In vitro Inhibitory activity tested at 5-hydroxytryptamine 1A receptor binding site in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Uppsala

Curated by ChEMBL
LigandPNGBDBM50011247(S-(-)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthale...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity to 5HT1A receptor in Sprague-Dawley rat brain cortex homogenates after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Uppsala

Curated by ChEMBL
LigandPNGBDBM50011247(S-(-)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthale...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity against 5-hydroxytryptamine 1A receptor of rat hippocampus tissue.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Uppsala

Curated by ChEMBL
LigandPNGBDBM50011247(S-(-)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthale...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity of 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Uppsala

Curated by ChEMBL
LigandPNGBDBM50011247(S-(-)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthale...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of [3H]- 8-OH-DPAT binding to 5-HT1A-receptor from rat cerebral cortex membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

Target5-hydroxytryptamine receptor 1A(Rat)
University of Uppsala

Curated by ChEMBL
LigandPNGBDBM50011247(S-(-)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthale...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity against rat hippocampal 5-hydroxytryptamine 1A (5-HT1A) receptor determined using [3H]8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Uppsala

Curated by ChEMBL
LigandPNGBDBM50011247(S-(-)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthale...)
Affinity DataKi:  4.10nMAssay Description:Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Uppsala

Curated by ChEMBL
LigandPNGBDBM50011247(S-(-)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthale...)
Affinity DataKi:  6.10nMAssay Description:Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50011247(S-(-)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthale...)
Affinity DataKi:  7.60nMAssay Description:Displacement of [3H]-5-carboxamidotryptamine from human 5-HT1A receptor expressed in HEK293T cell membranes incubated for 90 mins by scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Uppsala

Curated by ChEMBL
LigandPNGBDBM50011247(S-(-)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthale...)
Affinity DataKi:  8.40nMAssay Description:In vitro binding affinity against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in CHO cells (sc)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50011247(S-(-)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthale...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of GöTeborg

Curated by ChEMBL
LigandPNGBDBM50011247(S-(-)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthale...)
Affinity DataKi:  5.07E+3nMAssay Description:Displacement of [3H]spiperone from dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed