BDBM50011236 CHEMBL344314::Isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide::Isoquinolinesulfonamide, H-9::N-(2-aminoethyl)isoquinoline-5-sulfonamide

SMILES c1cc2cnccc2c(c1)S(=O)(=O)NCCN

InChI Key InChIKey=DCVZSHVZGVWQKV-UHFFFAOYSA-N

Data  8 IC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50011236   

TargetCasein kinase I isoform alpha(Human)
Nagoya University School of Medicine

LigandPNGBDBM50011236(Isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide...)
Affinity DataIC50: 1.10E+5nMpH: 7.4 T: 2°CAssay Description:Casein kinase activities were determined under the conditions as described by Huang et al (1982).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2013
Entry Details
PubMed
TargetCasein kinase II subunit alpha(Human)
Nagoya University School of Medicine

LigandPNGBDBM50011236(Isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide...)
Affinity DataIC50: 3.00E+5nMpH: 7.4 T: 2°CAssay Description:Casein kinase activities were determined under the conditions as described by Huang et al (1982).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2013
Entry Details
PubMed
TargetProtein kinase C alpha type(Human)
Nagoya University School of Medicine

LigandPNGBDBM50011236(Isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide...)
Affinity DataIC50: 1.80E+4nMpH: 7.4 T: 2°CAssay Description:Casein kinase activities were determined under the conditions as described by Huang et al (1982).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2013
Entry Details
PubMed
TargetcAMP-dependent protein kinase type I-alpha regulatory subunit(Bovine)
Nagoya University School of Medicine

LigandPNGBDBM50011236(Isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide...)
Affinity DataIC50: 3.60E+3nMpH: 7.4 T: 2°CAssay Description:Casein kinase activities were determined under the conditions as described by Huang et al (1982).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2013
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase II inhibitor 2(Bovine)
Nagoya University School of Medicine

LigandPNGBDBM50011236(Isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide...)
Affinity DataIC50: 5.80E+4nMpH: 7.4 T: 2°CAssay Description:Casein kinase activities were determined under the conditions as described by Huang et al (1982).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2013
Entry Details
PubMed
TargetMO15-related protein kinase Pfmrk(malaria parasite P. falciparum)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50011236(Isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide...)
Affinity DataIC50: 700nMAssay Description:Inhibition of Plasmodium falciparum PfmrkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50011236(Isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of cAMP-dependent protein kinase (PKA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2019
Entry Details Article
PubMed
LigandPNGBDBM50011236(Isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of protein kinase C (PKC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2019
Entry Details Article
PubMed