BDBM50010747 CHEMBL543201::CHEMBL78777::N,N'-Bis-(3-ethyl-phenyl)-guanidine

SMILES CCc1cccc(NC(N)=Nc2cccc(CC)c2)c1

InChI Key InChIKey=HCXWPWPGUTZRDL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50010747   

TargetSigma non-opioid intracellular receptor 1(Human)
Cambridge Neuroscience

Curated by ChEMBL
LigandPNGBDBM50010747(CHEMBL78777 | CHEMBL543201 | N,N'-Bis-(3-ethyl-phe...)
Affinity DataIC50: 8nMAssay Description:Tested in vitro for the concentration required to inhibit specific [3H]DTG radioligand binding to sigma receptor on guinea pig brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Cambridge Neuroscience

Curated by ChEMBL
LigandPNGBDBM50010747(CHEMBL78777 | CHEMBL543201 | N,N'-Bis-(3-ethyl-phe...)
Affinity DataIC50: 8.30nMAssay Description:In vitro inhibitory activity against [3H]-DTG in guinea pig brain membrane homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Cambridge Neuroscience

Curated by ChEMBL
LigandPNGBDBM50010747(CHEMBL78777 | CHEMBL543201 | N,N'-Bis-(3-ethyl-phe...)
Affinity DataIC50: 30nMAssay Description:Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensionsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Cambridge Neuroscience

Curated by ChEMBL
LigandPNGBDBM50010747(CHEMBL78777 | CHEMBL543201 | N,N'-Bis-(3-ethyl-phe...)
Affinity DataIC50: 30nMAssay Description:In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed