BDBM50010736 CHEMBL78083::N,N'-Bis-(4-ethyl-phenyl)-guanidine

SMILES CCc1ccc(NC(N)=Nc2ccc(CC)cc2)cc1

InChI Key InChIKey=DXGARAMIKHFTJV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50010736   

TargetSigma non-opioid intracellular receptor 1(Human)
Cambridge Neuroscience

Curated by ChEMBL
LigandPNGBDBM50010736(CHEMBL78083 | N,N'-Bis-(4-ethyl-phenyl)-guanidine)
Affinity DataIC50: 245nMAssay Description:Tested in vitro for the concentration required to inhibit specific [3H]DTG radioligand binding to sigma receptor on guinea pig brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Cambridge Neuroscience

Curated by ChEMBL
LigandPNGBDBM50010736(CHEMBL78083 | N,N'-Bis-(4-ethyl-phenyl)-guanidine)
Affinity DataIC50: 245nMAssay Description:In vitro inhibitory activity against [3H]-DTG in guinea pig brain membrane homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Cambridge Neuroscience

Curated by ChEMBL
LigandPNGBDBM50010736(CHEMBL78083 | N,N'-Bis-(4-ethyl-phenyl)-guanidine)
Affinity DataIC50: 1.39E+3nMAssay Description:Sodium channel block, determined by % block of [14C]guanidinium flux in CHO line expressing rat type IIA sodium channels derived from rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed