BDBM50010463 CHEMBL3092195

SMILES CNS(=O)(=O)Nc1cccc(Cc2c(C)c3ccc(Oc4ncccn4)cc3oc2=O)c1F

InChI Key InChIKey=XONVFTCAGXZIPY-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50010463   

TargetCytochrome P450 2C9(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50010463(CHEMBL3092195)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate measured after 30 mins preincubation by LC-MS/MS analysis in absence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50010463(CHEMBL3092195)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate measured after 30 mins preincubation by LC-MS/MS analysis in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50010463(CHEMBL3092195)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 30 mins preincubation by LC-MS/MS analysis in absence of N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50010463(CHEMBL3092195)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 30 mins preincubation by LC-MS/MS analysis in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50010463(CHEMBL3092195)
Affinity DataIC50: 23nMAssay Description:Inhibition of truncated active C-Raf (unknown origin) assessed as MEK1 phosphorylation using inactive MEK1 K97R as substrate after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50010463(CHEMBL3092195)
Affinity DataIC50: 97nMAssay Description:Inhibition of MEK1 (unknown origin) assessed as phosphorylation of Erk2 preincubated for 30 mins followed by FAM-Erktide addition measured after 60 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50010463(CHEMBL3092195)
Affinity DataIC50: 23nMAssay Description:Inhibition of C-Raf (unknown origin) assessed as phosphorylation of MEK1 after 45 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed