BDBM50009685 9-METHYL-9H-PURIN-6-AMINE::9-Methyl-9H-adenine::9-Methyl-9H-purin-6-ylamine::CHEMBL65976

SMILES Cn1cnc2c1ncnc2N

InChI Key InChIKey=WRXCXOUDSPTXNX-UHFFFAOYSA-N

Data  11 KI  4 IC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50009685   

TargetCyclin-dependent kinase 1(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50009685(CHEMBL65976 | 9-Methyl-9H-purin-6-ylamine | 9-Meth...)
Affinity DataIC50: 3.50E+5nMAssay Description:Inhibition of purified Cdc2 p34/Cyclin B obtained from M phase oocytes of the starfish Marthasterias glacialis (precipitation at the higher concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50009685(CHEMBL65976 | 9-Methyl-9H-purin-6-ylamine | 9-Meth...)
Affinity DataIC50: 1.47E+4nMAssay Description:Displacement of [3H]DPCPX from adenosine A1 receptor of rat cortical membranes with GTPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50009685(CHEMBL65976 | 9-Methyl-9H-purin-6-ylamine | 9-Meth...)
Affinity DataIC50: 1.25E+4nMAssay Description:Displacement of [3H]DPCPX from adenosine A1 receptor of rat cortical membranes without GTPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase type 2-alpha(Human)
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50009685(CHEMBL65976 | 9-Methyl-9H-purin-6-ylamine | 9-Meth...)
Affinity DataIC50: 1.61E+5nMAssay Description:Inhibitory activity (IC50) against human phosphatidylinositol 4-kinase at the ATP binding siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2019
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50009685(CHEMBL65976 | 9-Methyl-9H-purin-6-ylamine | 9-Meth...)
Affinity DataKi:  6.90E+3nMAssay Description:Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50009685(CHEMBL65976 | 9-Methyl-9H-purin-6-ylamine | 9-Meth...)
Affinity DataKi:  8.60E+3nMAssay Description:Binding affinity against Adenosine A2A receptor by using [3H]CGS-21680 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50009685(CHEMBL65976 | 9-Methyl-9H-purin-6-ylamine | 9-Meth...)
Affinity DataKi:  1.20E+4nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50009685(CHEMBL65976 | 9-Methyl-9H-purin-6-ylamine | 9-Meth...)
Affinity DataKi:  1.25E+4nMAssay Description:Affinity for the Adenosine A1 receptor in the absence of GTP (A1-GTP) by using [3H]DPCPX as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50009685(CHEMBL65976 | 9-Methyl-9H-purin-6-ylamine | 9-Meth...)
Affinity DataKi:  1.25E+4nMAssay Description:Affinity for the Adenosine A1 receptor in the absence of GTP (A1-GTP) by using [3H]DPCPX as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a/A2b(Rat)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50009685(CHEMBL65976 | 9-Methyl-9H-purin-6-ylamine | 9-Meth...)
Affinity DataKi:  1.50E+4nMAssay Description:Binding affinity against adenosine A2 receptor in rat striatum by using [3H]NECA as a radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a/A2b(Rat)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50009685(CHEMBL65976 | 9-Methyl-9H-purin-6-ylamine | 9-Meth...)
Affinity DataKi:  2.40E+4nMAssay Description:Tested for inhibition of rat PC12 adenylate cyclase stimulation by using NECA as a radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50009685(CHEMBL65976 | 9-Methyl-9H-purin-6-ylamine | 9-Meth...)
Affinity DataKi: >3.00E+4nMAssay Description:Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50009685(CHEMBL65976 | 9-Methyl-9H-purin-6-ylamine | 9-Meth...)
Affinity DataKi:  6.90E+4nMAssay Description:Binding affinity against adenosine A1 receptor in rat cortex by using [3H]- PIA as a radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50009685(CHEMBL65976 | 9-Methyl-9H-purin-6-ylamine | 9-Meth...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]NECA from human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2012
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase type 2-alpha(Human)
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50009685(CHEMBL65976 | 9-Methyl-9H-purin-6-ylamine | 9-Meth...)
Affinity DataKi:  1.11E+5nMAssay Description:Binding affinity (Ki) against human phosphatidylinositol 4-kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2019
Entry Details Article
PubMed