BDBM50009575 CHEMBL3234446

SMILES CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O

InChI Key InChIKey=SVWSKJCJNAIKNH-UHFFFAOYSA-N

Data  3 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50009575   

TargetApelin(Rat)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50009575(CHEMBL3234446)
Affinity DataIC50: 1.40nMAssay Description:Agonist activity at rat apelin receptor expressed in CHO cell membranes coexpressing EGFP assessed as inhibition of forskolin-induced cAMP production...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetApelin receptor(Rat)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50009575(CHEMBL3234446)
Affinity DataIC50: 0.0250nMAssay Description:Displacement of [125I]-(Glp1,Nle11,Try14)apelin-13 from recombinant rat EGFP-fused apelin receptor expressed in CHO cell membrane measured after 3 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetApelin receptor(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50009575(CHEMBL3234446)
Affinity DataEC50:  1.90nMAssay Description:Activation of recombinant human APJ expressed in rat Chem5 cells co-expressing Galpha15 by Calcium 6-QF dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetApelin(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50009575(CHEMBL3234446)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [125I]-pE13F from human apelin receptor expressed in CHO cell membranes after 1 hr by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetApelin receptor(Rat)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50009575(CHEMBL3234446)
Affinity DataKi:  0.0530nMAssay Description:Displacement of [125I]-pyr-1-apelin-13 from rat C-terminal EGFP-tagged APJ receptor expressed in CHO cell membranes after 3 hrs by Wallac gamma count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2019
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50009575(CHEMBL3234446)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [125I]-angiotensin 2 from human angiotensin 2 type-1 receptor expressed in CHO cell membranes after 1 hr by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed