BDBM50008714 CHEMBL3235981

SMILES C[C@@H](C(F)(F)F)NC(=O)N1CCc2cccnc2[C@H]1c3ccc(cc3)C(F)(F)F

InChI Key InChIKey=DDBWYSSPWMXBIY-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50008714   

TargetTransient receptor potential cation channel subfamily M member 8(Human)
Amgen

Curated by ChEMBL

LigandBDBM50008714(CHEMBL3235981)Copy SMILESCopy InChI

Affinity DataIC50: 25nMAssay Description:Antagonist activity at human TRPM8 assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior to icilin challenge by luminometryMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/7/2015
Entry Details Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
Amgen

Curated by ChEMBL

LigandBDBM50008714(CHEMBL3235981)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior to icilin chall...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/7/2015
Entry Details Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL