BDBM50007695 3-Piperazin-1-yl-benzo[d]isothiazole::Benzisothiazole-3-Yl-Piperazine (Bitp)::CHEMBL1154::CHEMBL1204336::EN300-230853

SMILES C1CN(CCN1)c1nsc2ccccc12

InChI Key InChIKey=KRDOFMHJLWKXIU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50007695   

Target5-hydroxytryptamine receptor 1A(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007695(CHEMBL1154 | 3-Piperazin-1-yl-benzo[d]isothiazole ...)
Affinity DataIC50: 190nMAssay Description:Binding affinity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue with [3H]5-HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007695(CHEMBL1154 | 3-Piperazin-1-yl-benzo[d]isothiazole ...)
Affinity DataIC50: 110nMAssay Description:Binding affinity against rat 5-hydroxytryptamine 2 receptor in rat cerebral cortex tissue using [3H]spiperone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50007695(CHEMBL1154 | 3-Piperazin-1-yl-benzo[d]isothiazole ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Compound was tested for its effect on dopamine saturation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50007695(CHEMBL1154 | 3-Piperazin-1-yl-benzo[d]isothiazole ...)
Affinity DataIC50: 510nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM50007695(CHEMBL1154 | 3-Piperazin-1-yl-benzo[d]isothiazole ...)
Affinity DataIC50: 3.34E+3nMAssay Description:IC50 values were determined for the whole plate in case of Chan-Lam coupling, using 5 point 3-fold dilutions (starting from 10 μM).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2023
Entry Details
PubMed