BDBM50007691 3-Oxo-2-oxa-spiro[4.4]nonane-1-carboxylic acid [4-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-butyl]-amide (1.4HCl)::CHEMBL321591

SMILES O=C(NCCCCN1CCN(CC1)c1nsc2ccccc12)C1OC(=O)CC11CCCC1

InChI Key InChIKey=OKYUOPQSBVIWPC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50007691   

Target5-hydroxytryptamine receptor 1A(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007691(CHEMBL321591 | 3-Oxo-2-oxa-spiro[4.4]nonane-1-carb...)
Affinity DataIC50: 99nMAssay Description:Binding affinity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue with [3H]5-HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007691(CHEMBL321591 | 3-Oxo-2-oxa-spiro[4.4]nonane-1-carb...)
Affinity DataIC50: 4.5nMAssay Description:Binding affinity against rat 5-hydroxytryptamine 2 receptor in rat cerebral cortex tissue using [3H]spiperone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007691(CHEMBL321591 | 3-Oxo-2-oxa-spiro[4.4]nonane-1-carb...)
Affinity DataIC50: 150nMAssay Description:Binding affinity against Dopamine receptor D2 receptor of rat corpus striatal tissue with [3H]spiperoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007691(CHEMBL321591 | 3-Oxo-2-oxa-spiro[4.4]nonane-1-carb...)
Affinity DataIC50: 2.5nMAssay Description:Binding affinity against alpha-1 adrenergic receptor in rat cerebral cortex tissue using [3H]WB-4101 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed