BDBM50007689 8-[4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-3-hydroxy-butyl]-2-hydroxy-8-aza-spiro[4.5]decane-7,9-dione (HCl.0.2H2O)::CHEMBL114131

SMILES OC(CCN1C(=O)CC2(CCC(O)C2)CC1=O)CN1CCN(CC1)c1nsc2ccccc12

InChI Key InChIKey=FEPIVRHFKXOYNY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50007689   

TargetD(2) dopamine receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007689(CHEMBL114131 | 8-[4-(4-Benzo[d]isothiazol-3-yl-pip...)
Affinity DataIC50: 491nMAssay Description:Binding affinity against Dopamine receptor D2 receptor of rat corpus striatal tissue with [3H]spiperoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007689(CHEMBL114131 | 8-[4-(4-Benzo[d]isothiazol-3-yl-pip...)
Affinity DataIC50: 14nMAssay Description:Binding affinity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue with [3H]5-HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007689(CHEMBL114131 | 8-[4-(4-Benzo[d]isothiazol-3-yl-pip...)
Affinity DataIC50: 20nMAssay Description:Binding affinity against rat 5-hydroxytryptamine 2 receptor in rat cerebral cortex tissue using [3H]spiperone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007689(CHEMBL114131 | 8-[4-(4-Benzo[d]isothiazol-3-yl-pip...)
Affinity DataIC50: 7.20nMAssay Description:Binding affinity against alpha-1 adrenergic receptor in rat cerebral cortex tissue using [3H]WB-4101 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed