BDBM50007140 1-Allylaminomethyl-3-cyclohexyl-isochroman-5,6-diol::CHEMBL419680

SMILES Oc1ccc2[C@H](CNCC=C)OC(Cc2c1O)C1CCCCC1

InChI Key InChIKey=NOOMHYKWRAKBNS-UHFFFAOYSA-N

Data  7 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50007140   

TargetD(2) dopamine receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50007140(CHEMBL419680 | 1-Allylaminomethyl-3-cyclohexyl-iso...)
Affinity DataEC50: >1.00E+4nMAssay Description:Concentration required to inhibit 50% dopamine receptor D2 in a cell free homogenate of intermediate lobe of pituitary glandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50007140(CHEMBL419680 | 1-Allylaminomethyl-3-cyclohexyl-iso...)
Affinity DataEC50:  47nMAssay Description:Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50007140(CHEMBL419680 | 1-Allylaminomethyl-3-cyclohexyl-iso...)
Affinity DataEC50:  30nMAssay Description:Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50007140(CHEMBL419680 | 1-Allylaminomethyl-3-cyclohexyl-iso...)
Affinity DataKi:  1.26E+3nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1C receptor using [125 I]-SCH23982 as radioligand in competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50007140(CHEMBL419680 | 1-Allylaminomethyl-3-cyclohexyl-iso...)
Affinity DataKi:  1.54E+3nMAssay Description:Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50007140(CHEMBL419680 | 1-Allylaminomethyl-3-cyclohexyl-iso...)
Affinity DataKi:  2.20E+3nMAssay Description:Binding affinity towards alpha-2 adrenergic receptor using [3H]rauwolscine as radioligand in competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50007140(CHEMBL419680 | 1-Allylaminomethyl-3-cyclohexyl-iso...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity towards beta-1 adrenergic receptor using [3H]iodocyanopindolol as radioligand in competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50007140(CHEMBL419680 | 1-Allylaminomethyl-3-cyclohexyl-iso...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity towards alpha-1 adrenergic receptor using [3H]prazosin as radioligand in competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50007140(CHEMBL419680 | 1-Allylaminomethyl-3-cyclohexyl-iso...)
Affinity DataKi: >2.00E+4nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand in competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50007140(CHEMBL419680 | 1-Allylaminomethyl-3-cyclohexyl-iso...)
Affinity DataKi: >2.00E+4nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2- receptor using [3H]ketanserin as radioligand in competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed