BDBM50006842 2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(3-isopropoxy-phenyl)-3H-quinazolin-4-one::CHEMBL37312

SMILES CC(C)Oc1cccc(c1)-n1c(CCc2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O

InChI Key InChIKey=KUECXUACQOYKNB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50006842   

TargetGastrin/cholecystokinin type B receptor(Mouse)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50006842(CHEMBL37312 | 2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-...)
Affinity DataIC50: 9.30nMAssay Description:Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50006842(CHEMBL37312 | 2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-...)
Affinity DataIC50: 160nMAssay Description:Inhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Mouse)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50006842(CHEMBL37312 | 2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-...)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Mouse)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50006842(CHEMBL37312 | 2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-...)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetGastrin/cholecystokinin type B receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50006842(CHEMBL37312 | 2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-...)
Affinity DataIC50: 81nMAssay Description:Antagonistic activity against cholecystokinin type B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50006842(CHEMBL37312 | 2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-...)
Affinity DataIC50: 81nMAssay Description:Inhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed