BDBM50005534 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)piperidine::1-(1-Benzo[b]thiophen-2-yl-cyclohexyl)-piperidine::1-(1-Benzo[b]thiophen-2-yl-cyclohexyl)-piperidine(BTCP)::1-[1-(3H-1lambda*4*-Benzo[b]thiophen-2-yl)-cyclohexyl]-piperidine::3-[(3-Chloro-phenyl)-phenyl-methoxy]-8-methyl-8-aza-bicyclo[3.2.1]octane::CHEMBL279556

SMILES C1CCN(CC1)C1(CCCCC1)c1cc2ccccc2s1

InChI Key InChIKey=RGSVXQJPSWZXOP-UHFFFAOYSA-N

Data  3 KI  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50005534   

TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50005534(CHEMBL279556 | 1-(1-(benzo[b]thiophen-2-yl)cyclohe...)
Affinity DataIC50: 41nMAssay Description:Inhibition of [3H]cocaine binding to rat forebrain dopamine receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50005534(CHEMBL279556 | 1-(1-(benzo[b]thiophen-2-yl)cyclohe...)
Affinity DataIC50: 11nMAssay Description:Tested for inhibition of radioligand [3H]dopamine (DA) uptake in rat synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50005534(CHEMBL279556 | 1-(1-(benzo[b]thiophen-2-yl)cyclohe...)
Affinity DataIC50: 5nMAssay Description:Tested for radioligand [3H]BTCP displacement from dopamine transporter in rat forebrainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50005534(CHEMBL279556 | 1-(1-(benzo[b]thiophen-2-yl)cyclohe...)
Affinity DataIC50: 42nMAssay Description:Inhibition of [3H]cocaine binding to the dopamine transporter.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50005534(CHEMBL279556 | 1-(1-(benzo[b]thiophen-2-yl)cyclohe...)
Affinity DataIC50: 8.40nMAssay Description:Inhibitory activity of compound against [3H]BTCP binding to neuronal dopamine transporter of rat striatal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50005534(CHEMBL279556 | 1-(1-(benzo[b]thiophen-2-yl)cyclohe...)
Affinity DataIC50: 2.80nMAssay Description:Displacement of [3H]BTCP from human recombinant dopamine transporter expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50005534(CHEMBL279556 | 1-(1-(benzo[b]thiophen-2-yl)cyclohe...)
Affinity DataIC50: 0.660nMAssay Description:Displacement of [3H]BTCP (1-[1-(2-benxo[b]thienyl)cyclohexyl]piperidine) from rat forebrain dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50005534(CHEMBL279556 | 1-(1-(benzo[b]thiophen-2-yl)cyclohe...)
Affinity DataIC50: 11nMAssay Description:Tested for inhibition of radioligand [3H]dopamine (DA) uptake in rat synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50005534(CHEMBL279556 | 1-(1-(benzo[b]thiophen-2-yl)cyclohe...)
Affinity DataIC50: 2.80nMAssay Description:Displacement of [3H]BTCP from human recombinant dopamine transporter expressed in CHO cells measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50005534(CHEMBL279556 | 1-(1-(benzo[b]thiophen-2-yl)cyclohe...)
Affinity DataIC50: 2nMAssay Description:Inhibition of [3H]WIN-35428 binding to the dopamine transporter.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50005534(CHEMBL279556 | 1-(1-(benzo[b]thiophen-2-yl)cyclohe...)
Affinity DataIC50: 5nMAssay Description:Inhibition of [3H]BTCP binding to the dopamine transporter.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50005534(CHEMBL279556 | 1-(1-(benzo[b]thiophen-2-yl)cyclohe...)
Affinity DataIC50: 20nMAssay Description:Inhibition of [3H]GBR-12935 binding to the dopamine transporter.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50005534(CHEMBL279556 | 1-(1-(benzo[b]thiophen-2-yl)cyclohe...)
Affinity DataIC50: 12nMAssay Description:Displacement of [3H]BTCP from human recombinant dopamine transporter expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2019
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50005534(CHEMBL279556 | 1-(1-(benzo[b]thiophen-2-yl)cyclohe...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]BTCP from human DA transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2013
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50005534(CHEMBL279556 | 1-(1-(benzo[b]thiophen-2-yl)cyclohe...)
Affinity DataKi:  6.20nMAssay Description:Displacement of [3H]BTCP from human recombinant dopamine transporter expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2019
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50005534(CHEMBL279556 | 1-(1-(benzo[b]thiophen-2-yl)cyclohe...)
Affinity DataKi:  10nMAssay Description:Binding affinity to dopamine transporter (DAT) using [3H]WIN-35428 as a radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed