BDBM50005020 CHEMBL2408784::US9650336, Example 9

SMILES CC1(C)Cc2ccc(cc2C11C=C(F)C(N)=N1)-c1cncnc1

InChI Key InChIKey=ORILNYIQHJPETP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50005020   

TargetBeta-secretase 1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50005020(CHEMBL2408784 | US9650336, Example 9)
Affinity DataIC50: 3.79E+3nMAssay Description:Inhibition of human BACE1 cloned in HEK293 cells using Eu-CEVNLDAEFK-QSY 7 as substrate preincubated for 10 mins followed by substrate addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50005020(CHEMBL2408784 | US9650336, Example 9)
Affinity DataIC50: 168nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells assessed as release of sAPPbeta after 17 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed
TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandPNGBDBM50005020(CHEMBL2408784 | US9650336, Example 9)
Affinity DataIC50: 3.79E+3nMAssay Description:The cDNA for the soluble part of the human 13-Secretase (AA 1-AA 460) was cloned using the ASP2-Fc10-1-IRES-GFP-neoK mammalian expression vector. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
Go to US Patent