BDBM50004659 CHEMBL321808::[2-(5-Dimethylaminomethyl-furan-2-ylmethylsulfanyl)-ethyl]-(4-nitro-pyridazin-3-yl)-amine

SMILES CN(C)Cc1ccc(CSCCNc2nnccc2[N+]([O-])=O)o1

InChI Key InChIKey=YSANROTYHBNTDV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50004659   

TargetMuscarinic acetylcholine receptor M2(Rat)
University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50004659(CHEMBL321808 | [2-(5-Dimethylaminomethyl-furan-2-y...)
Affinity DataIC50: 600nMAssay Description:Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50004659(CHEMBL321808 | [2-(5-Dimethylaminomethyl-furan-2-y...)
Affinity DataIC50: 470nMAssay Description:In vitro acetyl cholinesterase (AChE-I) inhibitory activity to determine its ability to reverse the cholinergic deficit characteristic of ADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Mouse)
University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50004659(CHEMBL321808 | [2-(5-Dimethylaminomethyl-furan-2-y...)
Affinity DataIC50: 970nMAssay Description:Binding affinity against mouse Muscarinic acetylcholine receptor M1 using cerebral cortex and [3H]pirenzepineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50004659(CHEMBL321808 | [2-(5-Dimethylaminomethyl-furan-2-y...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro Butyrylcholinesterase inhibitory activity to determine its ability to reverse the cholinergic deficit characteristic of ADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Horse)
University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50004659(CHEMBL321808 | [2-(5-Dimethylaminomethyl-furan-2-y...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine as substrate preincubated for 8 mins followed by substrate addition by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2018
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50004659(CHEMBL321808 | [2-(5-Dimethylaminomethyl-furan-2-y...)
Affinity DataIC50: 470nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine as substrate preincubated for 8 mins followed by substrate addition by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2018
Entry Details Article
PubMed