BDBM50004169 (2S,3S)-3-(4-Chloro-phenyl)-8-methyl-2-vinyl-8-aza-bicyclo[3.2.1]octane::3-(4-Chloro-phenyl)-8-methyl-2-vinyl-8-aza-bicyclo[3.2.1]octane::CHEMBL281288

SMILES CN1C2CCC1[C@@H](C=C)[C@H](C2)c1ccc(Cl)cc1

InChI Key

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50004169   

LigandPNGBDBM50004169(3-(4-Chloro-phenyl)-8-methyl-2-vinyl-8-aza-bicyclo...)
Affinity DataIC50: 2.80nMAssay Description:Inhibitory concentration against [3H]dopamine uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetSodium-dependent dopamine transporter(Rat)
Mayo Foundation

Curated by ChEMBL
LigandPNGBDBM50004169(3-(4-Chloro-phenyl)-8-methyl-2-vinyl-8-aza-bicyclo...)
Affinity DataIC50: 1.20nMAssay Description:Compound was evaluated for its ability to displace [3H]mazindol binding from rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50004169(3-(4-Chloro-phenyl)-8-methyl-2-vinyl-8-aza-bicyclo...)
Affinity DataIC50: 1.20nMAssay Description:Ability to displace [3H]-Mazindol from dopamine receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetSodium-dependent dopamine transporter(Rat)
Mayo Foundation

Curated by ChEMBL
LigandPNGBDBM50004169(3-(4-Chloro-phenyl)-8-methyl-2-vinyl-8-aza-bicyclo...)
Affinity DataKi:  0.590nMAssay Description:Binding affinity towards dopamine transporter using [3H]-mazindol as radioligand in rat striatal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Mayo Foundation

Curated by ChEMBL
LigandPNGBDBM50004169(3-(4-Chloro-phenyl)-8-methyl-2-vinyl-8-aza-bicyclo...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of [3H]dopamine binding to rat striatal synaptosome dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed