BDBM50003994 CHEMBL2180010::US9579407, Example 00161

SMILES COc1cn(nc(-c2ccnn2-c2ccccc2)c1=O)-c1ccc(cc1F)N1CC(F)(F)C1

InChI Key InChIKey=NHGUCDQJCLZXHH-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50003994   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50003994(CHEMBL2180010 | US9579407, Example 00161)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:Inhibition of human full length PDE10A expressed in SF21 cells using [3H]cGMP as substrate after 60 mins by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
5/17/2013
Entry Details Article
Copy Entry DOIPubMed
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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50003994(CHEMBL2180010 | US9579407, Example 00161)Copy SMILESCopy InChI

Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:Human PDE1A, 3A, 4D2, 5A1, 7B, 8A1, 9A2, and 11A4 enzymes were purchased from BPS Bioscience. Human PDE6AB enzyme was purchased from Scottish Biomedi...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/19/2019
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL