BDBM50003738 (lactone 2)N-[4-(6-Iodomethylene-2-oxo-tetrahydro-pyran-3-yl)-benzyl]-guanidine::CHEMBL135723

SMILES NC(=N)NCc1ccc(cc1)C1CC\C(OC1=O)=C\I

InChI Key InChIKey=HNGQAWXKSWVXIP-UHFFFAOYSA-N

Data  5 KI  1 Koff

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50003738   

TargetProthrombin(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50003738(CHEMBL135723 | (lactone 2)N-[4-(6-Iodomethylene-2-...)
Affinity DataKon:  0.000220M-1s-1Assay Description:Compound was tested for the rate constant of deacylation against thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50003738(CHEMBL135723 | (lactone 2)N-[4-(6-Iodomethylene-2-...)
Affinity DataKi:  10nMAssay Description:Compound was tested for its binding affinity against the enzyme Urokinase-type plasminogen activatorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50003738(CHEMBL135723 | (lactone 2)N-[4-(6-Iodomethylene-2-...)
Affinity DataKi:  80nMAssay Description:Compound was tested for its binding affinity against the enzyme trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50003738(CHEMBL135723 | (lactone 2)N-[4-(6-Iodomethylene-2-...)
Affinity DataKi:  120nMAssay Description:Compound was tested for its binding affinity against the enzyme Tissue plasminogen activatorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50003738(CHEMBL135723 | (lactone 2)N-[4-(6-Iodomethylene-2-...)
Affinity DataKi:  1.19E+3nMAssay Description:Compound was tested for the rate constant of deacylation against Urokinase-type plasminogen activatorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50003738(CHEMBL135723 | (lactone 2)N-[4-(6-Iodomethylene-2-...)
Affinity DataKi:  1.48E+4nMAssay Description:Compound was tested for the rate constant of deacylation against thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed