BDBM50003331 CHEMBL101322::CHEMBL1204312::N-[4-oxo-1'-[2-(2-pyridyl)ethyl]spiro[3,4-dihydro-2H-chromene-2,4'-(hexahydropyridine)]-6-yl]methanesulfonamide

SMILES CS(=O)(=O)Nc1ccc2OC3(CCN(CCc4ccccn4)CC3)CC(=O)c2c1

InChI Key InChIKey=XKYLWRMBNQDHDM-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50003331   

TargetAlpha-1A adrenergic receptor(Bovine)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003331(CHEMBL1204312 | CHEMBL101322 | N-[4-oxo-1'-[2-(2-p...)
Affinity DataIC50: 500nMAssay Description:Compound was evaluated for binding affinity at bovine brain Alpha-1 adrenergic receptor in a filtration-based assay using [3H]prazosin as the radioli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50003331(CHEMBL1204312 | CHEMBL101322 | N-[4-oxo-1'-[2-(2-p...)
Affinity DataKi: >2.00E+3nMAssay Description:Displacement of [125I]HEAT from human Alpha-1B adrenergic receptor expressed in LM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50003331(CHEMBL1204312 | CHEMBL101322 | N-[4-oxo-1'-[2-(2-p...)
Affinity DataKi: >2.00E+3nMAssay Description:Ability to displace [125I]HEAT from cloned human Alpha-1A adrenergic receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50003331(CHEMBL1204312 | CHEMBL101322 | N-[4-oxo-1'-[2-(2-p...)
Affinity DataKi:  3.84E+3nMAssay Description:Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed