BDBM50003187 CHEMBL92538::[1-(4-Cyclohexylmethyl-3-hydroxy-2,6,10-trioxo-1-oxa-5,9-diaza-cyclotetradec-7-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester

SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CNC(=O)CCCCOC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O

InChI Key InChIKey=UFBZILSGLCZWAN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50003187   

TargetRenin(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003187(CHEMBL92538 | [1-(4-Cyclohexylmethyl-3-hydroxy-2,6...)
Affinity DataIC50: 590nMpH: 7.4Assay Description:The compound was evaluated in vitro for inhibition of human plasma renin at pH 7.4.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003187(CHEMBL92538 | [1-(4-Cyclohexylmethyl-3-hydroxy-2,6...)
Affinity DataIC50: 590nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003187(CHEMBL92538 | [1-(4-Cyclohexylmethyl-3-hydroxy-2,6...)
Affinity DataIC50: 590nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed