BDBM50003127 CHEMBL122193::CHEMBL1626562::CHEMBL16659::choline salt of 5-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3H-[1,3,4]thiadiazole-2-thione

SMILES CC(C)(C)c1cc(cc(c1O)C(C)(C)C)-c1nnc(S)s1

InChI Key InChIKey=MYNMGQGXYYHMEX-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50003127   

TargetProstaglandin G/H synthase 1(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50003127(CHEMBL1626562 | CHEMBL16659 | CHEMBL122193 | choli...)
Affinity DataIC50: 2.00E+4nMAssay Description:IC50 value against ovine Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50003127(CHEMBL1626562 | CHEMBL16659 | CHEMBL122193 | choli...)
Affinity DataIC50: 2.00E+4nMAssay Description:IC50 value against Prostaglandin G/H synthase 1 of human platelet rich plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50003127(CHEMBL1626562 | CHEMBL16659 | CHEMBL122193 | choli...)
Affinity DataIC50: 350nMAssay Description:IC50 value against Prostaglandin G/H synthase 2 of murine J774A.1 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50003127(CHEMBL1626562 | CHEMBL16659 | CHEMBL122193 | choli...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of recombinant human prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50003127(CHEMBL1626562 | CHEMBL16659 | CHEMBL122193 | choli...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of 5-LO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
LigandPNGBDBM50003127(CHEMBL1626562 | CHEMBL16659 | CHEMBL122193 | choli...)
Affinity DataIC50: 2.80E+3nMAssay Description:The compound was tested for the inhibition of 5-lipoxygenase in intact basophilic rat leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

LigandPNGBDBM50003127(CHEMBL1626562 | CHEMBL16659 | CHEMBL122193 | choli...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of 5-lipoxygenase measured by the reduction of leukotriene B4 (LTB4) in intact basophilic rat leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
LigandPNGBDBM50003127(CHEMBL1626562 | CHEMBL16659 | CHEMBL122193 | choli...)
Affinity DataIC50: 2.80E+3nMAssay Description:Evaluated in vitro for its inhibitory activity against 5-lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50003127(CHEMBL1626562 | CHEMBL16659 | CHEMBL122193 | choli...)
Affinity DataIC50: 800nMAssay Description:Evaluated in vitro for its inhibitory activity against Prostaglandin G/H synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50003127(CHEMBL1626562 | CHEMBL16659 | CHEMBL122193 | choli...)
Affinity DataIC50: 800nMAssay Description:The compound was tested for the inhibition of Prostaglandin G/H synthase in intact basophilic rat leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article