BDBM50003058 2-[4-(7-Amino-9-oxo-8,9-dihydro-2,5,6,8-tetraaza-cyclopenta[a]naphthalen-2-yl)-benzoylamino]-pentanedioic acid::CHEMBL331208

SMILES Nc1nc(O)c2c3cn(cc3cnc2n1)-c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O

InChI Key InChIKey=DAWDAGQDTYQILT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50003058   

TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50003058(CHEMBL331208 | 2-[4-(7-Amino-9-oxo-8,9-dihydro-2,5...)
Affinity DataIC50: 9.50E+4nMAssay Description:Compound was evaluated for the inhibition of Glycinamide ribonucleotide formyl transferase (GAR) with formyl (6R) tetrahydrofolate as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Lactobacillus casei)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50003058(CHEMBL331208 | 2-[4-(7-Amino-9-oxo-8,9-dihydro-2,5...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compound was evaluated for the inhibition of Lactobacillus casei thymidylate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50003058(CHEMBL331208 | 2-[4-(7-Amino-9-oxo-8,9-dihydro-2,5...)
Affinity DataIC50: 8.00E+4nMAssay Description:Compound was evaluated for the inhibition of recombinant human Dihydrofolate reductase (DHFR); no inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50003058(CHEMBL331208 | 2-[4-(7-Amino-9-oxo-8,9-dihydro-2,5...)
Affinity DataIC50: 1.70E+4nMAssay Description:Compound was evaluated for the inhibition of Aminoimidazole carboxamide ribonucleotide formyl transferase (AICAR) with (6R) tetrahydrofolate as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed