BDBM50003037 2-(3-Methyl-3,7,8,9-tetrahydro-pyrano[3,2-e]indol-1-yl)-ethylamine::CHEMBL25800

SMILES Cn1cc(CCN)c2c3CCCOc3ccc12

InChI Key InChIKey=CCGPJPFGXFZHAJ-UHFFFAOYSA-N

Data  3 KI  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50003037   

Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003037(CHEMBL25800 | 2-(3-Methyl-3,7,8,9-tetrahydro-pyran...)
Affinity DataIC50: 100nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1C receptor in pig choroid plexus using [3H]mesulergine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003037(CHEMBL25800 | 2-(3-Methyl-3,7,8,9-tetrahydro-pyran...)
Affinity DataIC50: 4.20E+3nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003037(CHEMBL25800 | 2-(3-Methyl-3,7,8,9-tetrahydro-pyran...)
Affinity DataIC50: 5.30E+3nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat cortex using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50003037(CHEMBL25800 | 2-(3-Methyl-3,7,8,9-tetrahydro-pyran...)
Affinity DataEC50:  213nMAssay Description:In vitro relative agonist activity against 5-hydroxytryptamine 2A using PI assay in rat vascular smooth muscle cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50003037(CHEMBL25800 | 2-(3-Methyl-3,7,8,9-tetrahydro-pyran...)
Affinity DataIC50: 2.80nMAssay Description:In vitro inhibition of [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50003037(CHEMBL25800 | 2-(3-Methyl-3,7,8,9-tetrahydro-pyran...)
Affinity DataIC50: 8.41E+3nMAssay Description:In vitro inhibitory concentration required against [3H]8-OH-DPAT binding to cloned human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003037(CHEMBL25800 | 2-(3-Methyl-3,7,8,9-tetrahydro-pyran...)
Affinity DataIC50: 14nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 2 receptor in rat anterior cortex using [125I]DOI as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003037(CHEMBL25800 | 2-(3-Methyl-3,7,8,9-tetrahydro-pyran...)
Affinity DataIC50: 800nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 2 receptor in rat anterior cortex using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50003037(CHEMBL25800 | 2-(3-Methyl-3,7,8,9-tetrahydro-pyran...)
Affinity DataKi:  1.10nMAssay Description:In vitro inhibitory constant against [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50003037(CHEMBL25800 | 2-(3-Methyl-3,7,8,9-tetrahydro-pyran...)
Affinity DataKi:  8.20nMAssay Description:Inhibitory constant determined against cloned human 5-hydroxytryptamine 2A receptor using with [125I]- DOI radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003037(CHEMBL25800 | 2-(3-Methyl-3,7,8,9-tetrahydro-pyran...)
Affinity DataKi:  2.63E+3nMAssay Description:Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacementMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed