BDBM50002755 11-[2-(Benzenesulfonyl-methyl-amino)-ethylsulfanyl]-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid::CHEMBL114424

SMILES CN(CCSC1c2ccccc2COc2ccc(cc12)C(O)=O)S(=O)(=O)c1ccccc1

InChI Key InChIKey=GODBHXSVNOESLI-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50002755   

TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002755(CHEMBL114424 | 11-[2-(Benzenesulfonyl-methyl-amino...)
Affinity DataIC50: 2.20E+3nMAssay Description:Compound was tested for its inhibitory activity against TXA2 synthase obtained from bovine platelet microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Rat)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002755(CHEMBL114424 | 11-[2-(Benzenesulfonyl-methyl-amino...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibitory effect against thromboxane A2 synthase binding to bovine plateletsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002755(CHEMBL114424 | 11-[2-(Benzenesulfonyl-methyl-amino...)
Affinity DataKi:  33nMAssay Description:Compound was tested for its binding affinity at Thromboxane A2 receptor by measuring its ability to displace [3H]U-46619 from guinea pig plateletsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002755(CHEMBL114424 | 11-[2-(Benzenesulfonyl-methyl-amino...)
Affinity DataKi:  33nMAssay Description:Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]U-46619 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed