BDBM50002750 11-(2-Benzenesulfonylamino-ethylsulfanyl)-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid::CHEMBL324130

SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)c3ccccc3)c2c1

InChI Key InChIKey=WBPHAIFIMCCUJM-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50002750   

TargetThromboxane-A synthase(Rat)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002750(CHEMBL324130 | 11-(2-Benzenesulfonylamino-ethylsul...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibitory effect against thromboxane A2 synthase binding to bovine plateletsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002750(CHEMBL324130 | 11-(2-Benzenesulfonylamino-ethylsul...)
Affinity DataIC50: 2.40E+4nMAssay Description:Compound was tested for its inhibitory activity against TXA2 synthase obtained from bovine platelet microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002750(CHEMBL324130 | 11-(2-Benzenesulfonylamino-ethylsul...)
Affinity DataKi:  32nMAssay Description:Compound was tested for its binding affinity at Thromboxane A2 receptor by measuring its ability to displace [3H]U-46619 from guinea pig plateletsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002750(CHEMBL324130 | 11-(2-Benzenesulfonylamino-ethylsul...)
Affinity DataKi:  32nMAssay Description:Compound was tested for its binding affinity at Thromboxane A2/ Prostaglandin H2 receptor by measuring its ability to displace [3H]U-46619 from guine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002750(CHEMBL324130 | 11-(2-Benzenesulfonylamino-ethylsul...)
Affinity DataKi:  32nMAssay Description:Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]U-46619 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed