BDBM50001609 8-Benzyloxy-4-[(methyl-phenethyl-carbamoyl)-methyl]-naphthalene-2-carboxylic acid::8-Benzyloxy-4-[(methyl-phenethyl-carbamoyl)-methyl]-naphthalene-2-carboxylic acid (RG14893)::CHEMBL328712

SMILES CN(CCc1ccccc1)C(=O)Cc1cc(cc2c(OCc3ccccc3)cccc12)C(O)=O

InChI Key InChIKey=VPJQGXIZXVPFOC-UHFFFAOYSA-N

Data  5 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50001609   

TargetLeukotriene B4 receptor 1(Human)
Rhone-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50001609(CHEMBL328712 | 8-Benzyloxy-4-[(methyl-phenethyl-ca...)
Affinity DataIC50: 4.70nMAssay Description:Concentration inhibiting the binding of [3H]LTB4 to human whole cell neutrophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
Rhone-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50001609(CHEMBL328712 | 8-Benzyloxy-4-[(methyl-phenethyl-ca...)
Affinity DataIC50: 4.70nMAssay Description:Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
Rhone-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50001609(CHEMBL328712 | 8-Benzyloxy-4-[(methyl-phenethyl-ca...)
Affinity DataIC50: 9nMAssay Description:Antagonistic activity against monkey neutrophil LTB4 receptor 2 min after an iv dose of 3 mg/kg. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
Rhone-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50001609(CHEMBL328712 | 8-Benzyloxy-4-[(methyl-phenethyl-ca...)
Affinity DataIC50: 0.360nMAssay Description:Antagonistic activity against LTB4 receptor using guinea pig (GP) spleen cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
Rhone-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50001609(CHEMBL328712 | 8-Benzyloxy-4-[(methyl-phenethyl-ca...)
Affinity DataIC50: 0.800nMAssay Description:Concentration inhibiting 1 nM LTB4-induced aggregation in GP polymorphonuclear (PMN) leukocytes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
Rhone-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50001609(CHEMBL328712 | 8-Benzyloxy-4-[(methyl-phenethyl-ca...)
Affinity DataKi:  0.140nMAssay Description:Affinity for guinea pig PMN LTB-4 receptors.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
Rhone-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50001609(CHEMBL328712 | 8-Benzyloxy-4-[(methyl-phenethyl-ca...)
Affinity DataKi:  2nMAssay Description:Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
Rhone-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50001609(CHEMBL328712 | 8-Benzyloxy-4-[(methyl-phenethyl-ca...)
Affinity DataKi:  2nMAssay Description:Binding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
Rhone-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50001609(CHEMBL328712 | 8-Benzyloxy-4-[(methyl-phenethyl-ca...)
Affinity DataKi:  2nMAssay Description:Affinity for human PMN LTB-4 receptors.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Sultan Moulay Slimane University

Curated by ChEMBL
LigandPNGBDBM50001609(CHEMBL328712 | 8-Benzyloxy-4-[(methyl-phenethyl-ca...)
Affinity DataKi:  2nMAssay Description:Antagonist activity against LTB4 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed