BDBM50001514 1-Ethyl-3-methyl-3,7-dihydro-purine-2,6-dione::CHEMBL24107

SMILES CCn1c(=O)n(C)c2nc[nH]c2c1=O

InChI Key InChIKey=KVSRUALMCYFLEP-UHFFFAOYSA-N

Data  9 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50001514   

TargetAdenosine receptor A2a(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50001514(CHEMBL24107 | 1-Ethyl-3-methyl-3,7-dihydro-purine-...)
Affinity DataEC50:  1.52E+4nMAssay Description:Relaxant activity on the spontaneous tone of isolated guinea pig tracheal ring chains.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
National Institute of Diabetes & Digestive & Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50001514(CHEMBL24107 | 1-Ethyl-3-methyl-3,7-dihydro-purine-...)
Affinity DataKi:  1.62E+3nMAssay Description:Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50001514(CHEMBL24107 | 1-Ethyl-3-methyl-3,7-dihydro-purine-...)
Affinity DataKi:  5.00E+3nMAssay Description:Compound was evaluated for its ability to antagonise cyclic [3H]AMP accumulation in [3H]adenine-labeled guinea pig cerebral cortical slices.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes & Digestive & Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50001514(CHEMBL24107 | 1-Ethyl-3-methyl-3,7-dihydro-purine-...)
Affinity DataKi:  9.78E+3nMAssay Description:Binding affinity at rat Adenosine A2A receptor by [3H]-CGS- 21680 displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Guinea pig)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50001514(CHEMBL24107 | 1-Ethyl-3-methyl-3,7-dihydro-purine-...)
Affinity DataKi:  9.80E+3nMAssay Description:Affinity against adenosine A1 receptor in the brain membranes by the displacement of [3H]CPX.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50001514(CHEMBL24107 | 1-Ethyl-3-methyl-3,7-dihydro-purine-...)
Affinity DataKi:  1.50E+4nMAssay Description:Ability to inhibit binding of 1 nM [3H]cyclohexyladenosine to adenosine A1 receptor in rat cerebral cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50001514(CHEMBL24107 | 1-Ethyl-3-methyl-3,7-dihydro-purine-...)
Affinity DataKi:  1.50E+4nMAssay Description:Binding affinity at A1 adenosine receptor in rat brain cortical membrane using [3H]- N6-R-phenylisopropyladenosine (R-PIA)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a/A2b(Rat)
Pharmazeutische Chemie

Curated by ChEMBL
LigandPNGBDBM50001514(CHEMBL24107 | 1-Ethyl-3-methyl-3,7-dihydro-purine-...)
Affinity DataKi:  2.30E+4nMAssay Description:Binding affinity against Adenosine A2 receptor in rat striatal membranes using [3H]5'-(N-ethylcarboxamido)-adenosine (NECA) as the ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50001514(CHEMBL24107 | 1-Ethyl-3-methyl-3,7-dihydro-purine-...)
Affinity DataKi:  2.47E+4nMAssay Description:Binding affinity of specific [3H]R-PIA binding to rat Adenosine A1 receptor in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50001514(CHEMBL24107 | 1-Ethyl-3-methyl-3,7-dihydro-purine-...)
Affinity DataKi:  2.50E+4nMAssay Description:Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed