BDBM50001496 7-Ethyl-1-methyl-3-propyl-3,7-dihydro-purine-2,6-dione::CHEMBL283412

SMILES CCCn1c2ncn(CC)c2c(=O)n(C)c1=O

InChI Key InChIKey=MBUIHYBKDMAGEF-UHFFFAOYSA-N

Data  6 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50001496   

TargetAdenosine receptor A2a(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50001496(CHEMBL283412 | 7-Ethyl-1-methyl-3-propyl-3,7-dihyd...)
Affinity DataEC50:  5.90E+3nMAssay Description:Relaxant activity on the spontaneous tone of isolated guinea pig tracheal ring chains.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Guinea pig)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50001496(CHEMBL283412 | 7-Ethyl-1-methyl-3-propyl-3,7-dihyd...)
Affinity DataKi:  1.42E+4nMAssay Description:Affinity against adenosine A1 receptor in the brain membranes by the displacement of [3H]CPX.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Guinea pig)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50001496(CHEMBL283412 | 7-Ethyl-1-methyl-3-propyl-3,7-dihyd...)
Affinity DataKi:  1.42E+4nMAssay Description:Binding affinity against Adenosine A1 receptor of cerebral cortex using [3H]-CPXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Guinea pig)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50001496(CHEMBL283412 | 7-Ethyl-1-methyl-3-propyl-3,7-dihyd...)
Affinity DataKi:  2.15E+4nMAssay Description:Affinity against adenosine A2 receptor in the brain membranes measured by the displacement of [3H]-CPXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a/A2b(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50001496(CHEMBL283412 | 7-Ethyl-1-methyl-3-propyl-3,7-dihyd...)
Affinity DataKi:  2.15E+4nMAssay Description:Binding affinity against adenosine A2 receptor of striatal membrane using [3H]CGS-21680 as a radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50001496(CHEMBL283412 | 7-Ethyl-1-methyl-3-propyl-3,7-dihyd...)
Affinity DataKi:  3.23E+4nMAssay Description:Inhibition of cyclic AMP-phosphodiesterase ( PDE) in the supernatant of tracheal muscle homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50001496(CHEMBL283412 | 7-Ethyl-1-methyl-3-propyl-3,7-dihyd...)
Affinity DataKi:  3.23E+4nMAssay Description:Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed