BDBM50001490 1-Propyl-3,7-dihydro-purine-2,6-dione::CHEMBL39986

SMILES CCCn1c(=O)[nH]c2nc[nH]c2c1=O

InChI Key InChIKey=IWBONKMODGBEOX-UHFFFAOYSA-N

Data  10 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50001490   

TargetAdenosine receptor A2a(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50001490(CHEMBL39986 | 1-Propyl-3,7-dihydro-purine-2,6-dion...)
Affinity DataEC50:  6.20E+4nMAssay Description:Relaxant activity on the spontaneous tone of isolated guinea pig tracheal ring chains.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
National Institute of Diabetes & Digestive & Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50001490(CHEMBL39986 | 1-Propyl-3,7-dihydro-purine-2,6-dion...)
Affinity DataKi:  360nMAssay Description:Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Rat)
National Institute of Diabetes & Digestive & Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50001490(CHEMBL39986 | 1-Propyl-3,7-dihydro-purine-2,6-dion...)
Affinity DataKi:  1.88E+3nMAssay Description:Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
National Institute of Diabetes & Digestive & Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50001490(CHEMBL39986 | 1-Propyl-3,7-dihydro-purine-2,6-dion...)
Affinity DataKi:  2.37E+3nMAssay Description:Inhibition of [125I]I-AB-MECA binding to human Adenosine A3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Guinea pig)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50001490(CHEMBL39986 | 1-Propyl-3,7-dihydro-purine-2,6-dion...)
Affinity DataKi:  3.30E+3nMAssay Description:Affinity against adenosine A1 receptor in the brain membranes by the displacement of [3H]CPX.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes & Digestive & Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50001490(CHEMBL39986 | 1-Propyl-3,7-dihydro-purine-2,6-dion...)
Affinity DataKi:  3.31E+3nMAssay Description:Binding affinity of [3H]R-PIA for rat Adenosine A2B receptor in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes & Digestive & Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50001490(CHEMBL39986 | 1-Propyl-3,7-dihydro-purine-2,6-dion...)
Affinity DataKi:  1.30E+4nMAssay Description:Binding affinity at A1 adenosine receptor in rat brain cortical membrane using [3H]- N6-R-phenylisopropyladenosine (R-PIA)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes & Digestive & Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50001490(CHEMBL39986 | 1-Propyl-3,7-dihydro-purine-2,6-dion...)
Affinity DataKi:  1.30E+4nMAssay Description:Binding affinity to A1 adenosine receptor from rat cortical membrane in presence of [3H]R-(phenylisopropyl)-adenosineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Guinea pig)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50001490(CHEMBL39986 | 1-Propyl-3,7-dihydro-purine-2,6-dion...)
Affinity DataKi:  2.34E+4nMAssay Description:Affinity against adenosine A2 receptor in the brain membranes measured by the displacement of [3H]-CPXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a/A2b(Rat)
Pharmazeutische Chemie

Curated by ChEMBL
LigandPNGBDBM50001490(CHEMBL39986 | 1-Propyl-3,7-dihydro-purine-2,6-dion...)
Affinity DataKi:  3.30E+4nMAssay Description:Binding affinity against Adenosine A2 receptor in rat striatal membranes using [3H]5'-(N-ethylcarboxamido)-adenosine (NECA) as the ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50001490(CHEMBL39986 | 1-Propyl-3,7-dihydro-purine-2,6-dion...)
Affinity DataKi:  4.93E+4nMAssay Description:Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed