BDBM50001114 8-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylmethyl)-7,8-dihydro-3H-6,9-dioxa-3-aza-cyclopenta[a]naphthalene-2-carboxylic acid methyl ester::CHEMBL320173

SMILES COC(=O)c1cc2c3OC(CN4CCC5(CC4)N(CNC5=O)c4ccccc4)COc3ccc2[nH]1

InChI Key InChIKey=HSOIWCPMXCWYHB-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50001114   

Target5-hydroxytryptamine receptor 1A(Human)
Upjohn

Curated by ChEMBL
LigandPNGBDBM50001114(CHEMBL320173 | 8-(4-Oxo-1-phenyl-1,3,8-triaza-spir...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Upjohn

Curated by ChEMBL
LigandPNGBDBM50001114(CHEMBL320173 | 8-(4-Oxo-1-phenyl-1,3,8-triaza-spir...)
Affinity DataKi:  3.10nMAssay Description:Compound was evaluated for the binding affinity towards Dopamine receptor D2 from mammalian clones expressed in CHO cell membranes using [3H]U-86170 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50001114(CHEMBL320173 | 8-(4-Oxo-1-phenyl-1,3,8-triaza-spir...)
Affinity DataKi:  6.5nMAssay Description:Binding affinity towards opioid receptor from rat whole brain using [3H]etorpine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50001114(CHEMBL320173 | 8-(4-Oxo-1-phenyl-1,3,8-triaza-spir...)
Affinity DataKi:  11nMAssay Description:Compound was evaluated for the binding affinity towards Alpha-1 adrenergic receptor from rat whole brain using [3H]prazosin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed