BDBM50001043 6,11-Dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol::CHEMBL94350

SMILES C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCc1ccccc1

InChI Key InChIKey=ZQHYKVKNPWDQSL-UHFFFAOYSA-N

Data  14 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50001043   

TargetMu-type opioid receptor(Guinea pig)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50001043(CHEMBL94350 | 6,11-Dimethyl-3-phenethyl-1,2,3,4,5,...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in guinea pig brain membrane incubated for 2.5 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50001043(CHEMBL94350 | 6,11-Dimethyl-3-phenethyl-1,2,3,4,5,...)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]-PTZ from sigma1 receptor in guinea pig brain membranes after 150 mins in presence of 1 mM DPH by liquid scintillation counting m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2019
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50001043(CHEMBL94350 | 6,11-Dimethyl-3-phenethyl-1,2,3,4,5,...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H] DAMGO from mu opioid receptor in Sprague-Dawley rat whole brain membranes after 2.5 hrs by liquid scintillation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2019
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50001043(CHEMBL94350 | 6,11-Dimethyl-3-phenethyl-1,2,3,4,5,...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]-PTZ from sigma1 receptor in guinea pig brain membranes after 150 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2019
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM50001043(CHEMBL94350 | 6,11-Dimethyl-3-phenethyl-1,2,3,4,5,...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHO-K1 cell membranes incubated for 90 mins measured by MicroBeta scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50001043(CHEMBL94350 | 6,11-Dimethyl-3-phenethyl-1,2,3,4,5,...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]pentazocine from guinea pig brain membrane sigma 1 receptor incubated for 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50001043(CHEMBL94350 | 6,11-Dimethyl-3-phenethyl-1,2,3,4,5,...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]-PTZ from sigma1 receptor in guinea pig brain membranes after 150 mins in presence of 1 mM DPH by liquid scintillation counting m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2019
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50001043(CHEMBL94350 | 6,11-Dimethyl-3-phenethyl-1,2,3,4,5,...)
Affinity DataKi:  55nMAssay Description:Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50001043(CHEMBL94350 | 6,11-Dimethyl-3-phenethyl-1,2,3,4,5,...)
Affinity DataKi:  55nMAssay Description:Displacement of [3H]-(+)-pentazocin from sigma1 receptor in guinea pig brain P2 membranes after 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2019
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50001043(CHEMBL94350 | 6,11-Dimethyl-3-phenethyl-1,2,3,4,5,...)
Affinity DataKi:  55nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM50001043(CHEMBL94350 | 6,11-Dimethyl-3-phenethyl-1,2,3,4,5,...)
Affinity DataKi:  55nMAssay Description:Binding affinity to mu opioid receptor (unknown origin) assessed as inhibition constant in presence of LevorphanolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50001043(CHEMBL94350 | 6,11-Dimethyl-3-phenethyl-1,2,3,4,5,...)
Affinity DataKi:  62nMAssay Description:Displacement of [3H]-(+)-pnetazocin from sigma1 receptor in guinea pig brain membrane incubated for 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50001043(CHEMBL94350 | 6,11-Dimethyl-3-phenethyl-1,2,3,4,5,...)
Affinity DataKi:  123nMAssay Description:Displacement of [3H]DPDPE from delta opioid receptor in Sprague-Dawley rat brain membranes by liquid scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2019
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50001043(CHEMBL94350 | 6,11-Dimethyl-3-phenethyl-1,2,3,4,5,...)
Affinity DataKi:  175nMAssay Description:Displacement of [3H]U69,593 from kappa opioid receptor in guinea pig brain membranes by liquid scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2019
Entry Details Article
PubMed