BDBM50000906 7-(4-Morpholin-4-yl-4-oxo-butoxy)-1,3-dihydro-imidazo[4,5-b]quinolin-2-one::CHEMBL89660

SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)N1CCOCC1

InChI Key InChIKey=AXOWWPSGJNHDFB-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50000906   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000906(CHEMBL89660 | 7-(4-Morpholin-4-yl-4-oxo-butoxy)-1,...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetP2Y purinoceptor 12(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000906(CHEMBL89660 | 7-(4-Morpholin-4-yl-4-oxo-butoxy)-1,...)
Affinity DataEC50:  280nMAssay Description:Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000906(CHEMBL89660 | 7-(4-Morpholin-4-yl-4-oxo-butoxy)-1,...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed