BDBM50000883 1-Methyl-7-(4-oxo-4-piperidin-1-yl-butoxy)-1,3-dihydro-imidazo[4,5-b]quinolin-2-one::CHEMBL313282

SMILES Cn1c2cc3cc(OCCCC(=O)N4CCCCC4)ccc3nc2[nH]c1=O

InChI Key InChIKey=NEXQSNFNHKOAMU-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50000883   

TargetP2Y purinoceptor 12(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000883(CHEMBL313282 | 1-Methyl-7-(4-oxo-4-piperidin-1-yl-...)
Affinity DataEC50:  1.09E+4nMAssay Description:Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000883(CHEMBL313282 | 1-Methyl-7-(4-oxo-4-piperidin-1-yl-...)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000883(CHEMBL313282 | 1-Methyl-7-(4-oxo-4-piperidin-1-yl-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed