BDBM50000878 7-[3-(1H-Tetrazol-5-yl)-propoxy]-1,3-dihydro-imidazo[4,5-b]quinolin-2-one::CHEMBL88835

SMILES O=c1[nH]c2cc3cc(OCCCc4nnn[nH]4)ccc3nc2[nH]1

InChI Key InChIKey=VHMRDRDPCZRGKM-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50000878   

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000878(CHEMBL88835 | 7-[3-(1H-Tetrazol-5-yl)-propoxy]-1,3...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetP2Y purinoceptor 12(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000878(CHEMBL88835 | 7-[3-(1H-Tetrazol-5-yl)-propoxy]-1,3...)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetP2Y purinoceptor 12(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000878(CHEMBL88835 | 7-[3-(1H-Tetrazol-5-yl)-propoxy]-1,3...)
Affinity DataEC50:  6.32E+3nMAssay Description:Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed