BDBM50000871 CHEMBL69139::N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyramide::N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyramide(Lixazinone, RS 82856)::N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyramide(RS-82856)

SMILES CN(C1CCCCC1)C(=O)CCCOc1ccc2N=C3NC(=O)CN3Cc2c1

InChI Key InChIKey=WUECXCBONAGRSA-UHFFFAOYSA-N

Data  6 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50000871   

TargetP2Y purinoceptor 12(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000871(CHEMBL69139 | N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3...)
Affinity DataEC50:  440nMAssay Description:Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50000871(CHEMBL69139 | N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3...)
Affinity DataIC50: 10nMAssay Description:In vitro inhibition of cyclic AMP phosphodiesterase from human platelets.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details Article
PubMed
LigandPNGBDBM50000871(CHEMBL69139 | N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human platelet cAMP phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details Article
PubMed
LigandPNGBDBM50000871(CHEMBL69139 | N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3...)
Affinity DataIC50: 10nMAssay Description:Inhibition of platelet cAMP phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2018
Entry Details Article
PubMed
LigandPNGBDBM50000871(CHEMBL69139 | N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3...)
Affinity DataIC50: 6nMAssay Description:In vitro inhibitory activity against platelet phosphodiesterase (PDE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2018
Entry Details Article
PubMed
LigandPNGBDBM50000871(CHEMBL69139 | N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetP2Y purinoceptor 12(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000871(CHEMBL69139 | N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3...)
Affinity DataEC50:  100nMAssay Description:Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
The Baruch S. Blumberg Institute

Curated by ChEMBL
LigandPNGBDBM50000871(CHEMBL69139 | N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant PDE3 expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed