BDBM50000309 6-Imidazol-1-yl-3,4-dihydro-1H-quinolin-2-one::CHEMBL17516::US11401256, Example 1

SMILES O=C1CCc2cc(ccc2N1)-n1ccnc1

InChI Key InChIKey=BDMKPUAZENLRDY-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50000309   

TargetThromboxane-A synthase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000309(CHEMBL17516 | 6-Imidazol-1-yl-3,4-dihydro-1H-quino...)
Affinity DataIC50: 2.00E+3nMAssay Description:Compound was evaluated for the inhibition of human blood platelet,thromboxane A2 synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000309(CHEMBL17516 | 6-Imidazol-1-yl-3,4-dihydro-1H-quino...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human blood platelet c-AMP phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM50000309(CHEMBL17516 | 6-Imidazol-1-yl-3,4-dihydro-1H-quino...)
Affinity DataKd:  416nMAssay Description:Process 1) Optimization of measurement parameters to minimize protein consumption and to minimize the dilution effect and the DMSO content 2) Titrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
Go to US Patent