BDBM499829 (4-((cis-4-aminocyclohexyl)amino)-7H- pyrrolo[2,3-d]pyrimidin-5-yl)(2-chloro- 4-phenoxyphenyl)methanone::US11020398, Compound I-141

SMILES N[C@H]1CC[C@H](CC1)Nc1ncnc2[nH]cc(C(=O)c3ccc(Oc4ccccc4)cc3Cl)c12

InChI Key InChIKey=IUZZCPDVZWIZJE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 499829   

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandPNGBDBM499829((4-((cis-4-aminocyclohexyl)amino)-7H- pyrrolo[2,3-...)
Affinity DataIC50: 2.20nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandPNGBDBM499829((4-((cis-4-aminocyclohexyl)amino)-7H- pyrrolo[2,3-...)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of full length N-terminal GST fusion tagged human BTK expressed in baculovirus expression system using FAM-P2 peptide solution as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed