BDBM499812 (2-chloro-4-phenoxyphenyl)(4- (((3S,6R)-6-(hydroxymethyl)tetrahydro- 2H-pyran-3-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5-yl)methanone::US11020398, Compound I-124

SMILES OC[C@H]1CC[C@@H](CO1)Nc1ncnc2[nH]cc(C(=O)c3ccc(Oc4ccccc4)cc3Cl)c12

InChI Key InChIKey=JSFCZQSJQXFJDS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 499812   

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandPNGBDBM499812((2-chloro-4-phenoxyphenyl)(4- (((3S,6R)-6-(hydroxy...)
Affinity DataIC50: 9.70nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandPNGBDBM499812((2-chloro-4-phenoxyphenyl)(4- (((3S,6R)-6-(hydroxy...)
Affinity DataIC50: 9.70nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Arqule

US Patent
LigandPNGBDBM499812((2-chloro-4-phenoxyphenyl)(4- (((3S,6R)-6-(hydroxy...)
Affinity DataIC50: 7nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandPNGBDBM499812((2-chloro-4-phenoxyphenyl)(4- (((3S,6R)-6-(hydroxy...)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of full length N-terminal GST fusion tagged human BTK expressed in baculovirus expression system using FAM-P2 peptide solution as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandPNGBDBM499812((2-chloro-4-phenoxyphenyl)(4- (((3S,6R)-6-(hydroxy...)
Affinity DataIC50: 0.850nMAssay Description:Inhibition of wild type BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandPNGBDBM499812((2-chloro-4-phenoxyphenyl)(4- (((3S,6R)-6-(hydroxy...)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of BTK C481S mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed