BDBM498934 N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-phenyl-1,2,3,4-tetrahydropyrido[4,3-d]pyrimidin-7-yl)methyl)acrylamide::US11014923, Example 6

SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C(C2=O)c2ccccc2)c1F

InChI Key InChIKey=HYRSJVQEVBZKDV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 498934   

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM498934(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-p...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
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TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM498934(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-p...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM498934(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-p...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM498934(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-p...)
Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
Go to US Patent