BDBM498907 N-[(3S,4R)-1-(N~2~- cyclohexyl-D-lysyl)-3- {[(4-methylthiophen-2- yl)methyl]carbamoyl}pi- peridin-4-yl]-6- azaspiro[2.5]octane-6- carboxamide::US11014920, Compound 15

SMILES Cc1csc(CNC(=O)[C@H]2CN(CC[C@H]2NC(=O)N2CCC3(CC3)CC2)C(=O)[C@@H](CCCCN)NC2CCCCC2)c1

InChI Key InChIKey=ZKOVXVYVYTWPFS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 498907   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM498907(N-[(3S,4R)-1-(N~2~- cyclohexyl-D-lysyl)-3- {[(4-me...)
Affinity DataIC50: 60.2nMAssay Description:Factor XIIa activity determinations were made in 50 mM HEPES buffer containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
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