BDBM498901 (3S,4R)-4-{[(4-chloro- phenyl)carbonyl]amino}- 1-(N~2~- cyclohexyl- N~2~,N~6~,N~6~- trimethyl-D-lysyl)-N- (thiophen-2- ylmethyl)piperidine-3- carboxamide::US11014920, Compound 9

SMILES CN(C)CCCC[C@@H](N(C)C1CCCCC1)C(=O)N1CC[C@@H](NC(=O)c2ccc(Cl)cc2)[C@H](C1)C(=O)NCc1cccs1

InChI Key InChIKey=GHRXFMWFISZVRU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 498901   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM498901((3S,4R)-4-{[(4-chloro- phenyl)carbonyl]amino}- 1-(...)
Affinity DataIC50: 11.5nMAssay Description:Factor XIIa activity determinations were made in 50 mM HEPES buffer containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
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