BDBM498894 N-[4- (aminomethyl)benzyl]- 1-(N,3-dicyclohexyl-D- alanyl)-4-{[(5-methyl- 1,3-thiazol-2- yl)carbonyl]amino}pi- peridine-3-carboxamide::US11014920, Compound 2

SMILES Cc1cnc(s1)C(=O)NC1CCN(CC1C(=O)NCc1ccc(CN)cc1)C(=O)[C@@H](CC1CCCCC1)NC1CCCCC1

InChI Key InChIKey=FYZWIKCIWPOXNX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 498894   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM498894(N-[4- (aminomethyl)benzyl]- 1-(N,3-dicyclohexyl-D-...)
Affinity DataIC50: 73.3nMAssay Description:Factor XIIa activity determinations were made in 50 mM HEPES buffer containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent