BDBM498451 (1R,3S)-3-(3-{[(2- methoxypyridin-4- yl)acetyl]amino}-1H-pyrazol- 5-yl)cyclopentyl propan-2- ylcarbamate::US11014911, Example 276::US11718603, Example 276

SMILES COc1cc(CC(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)NC(C)C)ccn1

InChI Key InChIKey=JFXBJZCDBBMRSA-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 498451   

TargetCyclin-dependent kinase 2(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM498451((1R,3S)-3-(3-{[(2- methoxypyridin-4- yl)acetyl]am...)
Affinity DataIC50: 100nMAssay Description:Inhibition of NanoLuc-fused CDK2 (unknown origin) expressed in 293-NB2 cells incubated for 2 hrs in presence of tracer K10 by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
LigandPNGBDBM498451((1R,3S)-3-(3-{[(2- methoxypyridin-4- yl)acetyl]am...)
Affinity DataKi:  0.640nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
Go to US Patent

LigandPNGBDBM498451((1R,3S)-3-(3-{[(2- methoxypyridin-4- yl)acetyl]am...)
Affinity DataKi:  0.640nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandPNGBDBM498451((1R,3S)-3-(3-{[(2- methoxypyridin-4- yl)acetyl]am...)
Affinity DataKi:  33.1nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandPNGBDBM498451((1R,3S)-3-(3-{[(2- methoxypyridin-4- yl)acetyl]am...)
Affinity DataKi:  33.1nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
Go to US Patent