BDBM498220 US11014911, Example 45::US11718603, Example 45

SMILES CC[C@H](C)NC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2ccc(C)cc2S(C)(=O)=O)n[nH]1

InChI Key InChIKey=SOAVNZWYXCNFKF-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 498220   

LigandPNGBDBM498220(US11014911, Example 45 | US11718603, Example 45)
Affinity DataKi:  0.110nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
Go to US Patent

LigandPNGBDBM498220(US11014911, Example 45 | US11718603, Example 45)
Affinity DataKi:  0.110nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandPNGBDBM498220(US11014911, Example 45 | US11718603, Example 45)
Affinity DataKi:  61.4nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandPNGBDBM498220(US11014911, Example 45 | US11718603, Example 45)
Affinity DataKi:  61.4nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
Go to US Patent