BDBM497552 2,2,2-trifluoro-N-[(1R)-1-[2-[6-[(1S,8R)-5- (2,6-difluorophenyl)-11,11-dimethyl-3,4- diazatricyclo[6.2.1.02,7]undeca-2(7),3,5- trien-1-yl]pyrazin-2-yl]oxazol-4- yl]ethyl]ethanamine::US11008312, Example 52

SMILES C[C@@H](NCC(F)(F)F)c1coc(n1)-c1cncc(n1)[C@@]12CC[C@@H](c3cc(nnc13)-c1c(F)cccc1F)C2(C)C

InChI Key InChIKey=UFVPWAOSJKEMGR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 497552   

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandPNGBDBM497552(2,2,2-trifluoro-N-[(1R)-1-[2-[6-[(1S,8R)-5- (2,6-d...)
Affinity DataIC50: 5.40nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
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