BDBM497351 7-[[(1S)-1-[4-[2- Cyclopropyl-1-(4-prop-2- enoylpiperazin-1- yl)ethyl]phenyl]ethyl]amino]- 1-methyl-4H-pyrido[4,3- d][1,3]oxazin-2-one, isomer 1::US11001596, Example 10::US11001596, Example 9::US11629156, Example 9

SMILES C[C@H](Nc1cc2N(C)C(=O)OCc2cn1)c1ccc(cc1)[C@@H](CC1CC1)N1CCN(CC1)C(=O)C=C

InChI Key InChIKey=IUHLDGMZAYZHIR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 497351   

LigandPNGBDBM497351(US11001596, Example 10 | 7-[[(1S)-1-[4-[2- Cyclopr...)
Affinity DataIC50: 7.43nMAssay Description:IDH1-R132H, IDH1-R132C, IDH2-R172K and IDH2-R140Q mutant enzymes catalyze the conversion of αKG to 2HG. 2HG is analyzed using in-line solid phas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
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LigandPNGBDBM497351(US11001596, Example 10 | 7-[[(1S)-1-[4-[2- Cyclopr...)
Affinity DataIC50: 15.1nMAssay Description:IDH1-R132H, IDH1-R132C, IDH2-R172K and IDH2-R140Q mutant enzymes catalyze the conversion of αKG to 2HG. 2HG is analyzed using in-line solid phas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
Go to US Patent

LigandPNGBDBM497351(US11001596, Example 10 | 7-[[(1S)-1-[4-[2- Cyclopr...)
Affinity DataIC50: 13.9nMAssay Description:IDH1-R132H, IDH1-R132C, IDH2-R172K and IDH2-R140Q mutant enzymes catalyze the conversion of αKG to 2HG. 2HG is analyzed using in-line solid phas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
Go to US Patent

LigandPNGBDBM497351(US11001596, Example 10 | 7-[[(1S)-1-[4-[2- Cyclopr...)
Affinity DataIC50: 16.5nMAssay Description:IDH1-R132H, IDH1-R132C, IDH2-R172K and IDH2-R140Q mutant enzymes catalyze the conversion of αKG to 2HG. 2HG is analyzed using in-line solid phas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
Go to US Patent

LigandPNGBDBM497351(US11001596, Example 10 | 7-[[(1S)-1-[4-[2- Cyclopr...)
Affinity DataIC50: 7.43nMAssay Description:IDH1-R132H, IDH1-R132C, IDH2-R172K and IDH2-R140Q mutant enzymes catalyze the conversion of αKG to 2HG. 2HG is analyzed using in-line solid phas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2023
Entry Details
Go to US Patent

LigandPNGBDBM497351(US11001596, Example 10 | 7-[[(1S)-1-[4-[2- Cyclopr...)
Affinity DataIC50: 15.1nMAssay Description:IDH1-R132H, IDH1-R132C, IDH2-R172K and IDH2-R140Q mutant enzymes catalyze the conversion of αKG to 2HG. 2HG is analyzed using in-line solid phas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2023
Entry Details
Go to US Patent