BDBM497289 (4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pentan-2-yl)amino)- 7H-pyrrolo[2,3- d]pyrimidin-5-yl)piperidin- 1-yl)(pyrazin-2- yl)methanone::US11001586, Example 68

SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cnccn1

InChI Key InChIKey=BOHSEWFNQJXFAO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 497289   

TargetTyrosine-protein kinase Mer(Human)
The University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM497289((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50: 3nMAssay Description:Activity Against Mer Tyrosine Kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase receptor TYRO3(Human)
The University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM497289((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50: 275nMAssay Description:Activity Against Tyro3 Tyrosine Kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Mer(Human)
The University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM497289((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497289((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50: 470nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
The University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM497289((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50: 140nMAssay Description:Inhibition of TYRO3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497289((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50: 590nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed