BDBM497277 (2,6-dimethylpyridin-4- yl)(4-(2-(((1R,2R)-2- ethylcyclopropyl)amino)-7- ((1r,4R)-4- hydroxycyclohexyl)-7H- pyrrolo[2,3-d]pyrimidin-5- yl)piperidin-1- yl)methanone::US11001586, Example 56

SMILES CC[C@@H]1C[C@H]1Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1

InChI Key InChIKey=RCQLJPMEVONOSW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 497277   

TargetTyrosine-protein kinase Mer(Human)
The University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM497277((2,6-dimethylpyridin-4- yl)(4-(2-(((1R,2R)-2- ethy...)
Affinity DataIC50: 3nMAssay Description:Activity Against Mer Tyrosine Kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase receptor TYRO3(Human)
The University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM497277((2,6-dimethylpyridin-4- yl)(4-(2-(((1R,2R)-2- ethy...)
Affinity DataIC50: 750nMAssay Description:Activity Against Tyro3 Tyrosine Kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Mer(Human)
The University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM497277((2,6-dimethylpyridin-4- yl)(4-(2-(((1R,2R)-2- ethy...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497277((2,6-dimethylpyridin-4- yl)(4-(2-(((1R,2R)-2- ethy...)
Affinity DataIC50: 24nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
The University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM497277((2,6-dimethylpyridin-4- yl)(4-(2-(((1R,2R)-2- ethy...)
Affinity DataIC50: 73nMAssay Description:Inhibition of TYRO3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497277((2,6-dimethylpyridin-4- yl)(4-(2-(((1R,2R)-2- ethy...)
Affinity DataIC50: 55nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed